2010 Edith and Peter O'Donnell Awards Recipients
Medicine - Research Team of Renata Pasqualini, Ph.D. and Wadih Arap, MD., Ph.D.
Since they discovered that every normal or diseased organ in the human body has a unique address embedded in its vasculature, Drs. Renata Pasqualini and Wadih Arap have creatively exploited that knowledge to pursue targeted therapies and imaging agents for cancer and other diseases. They are developing delivery systems that “mail” toxic drugs, genes or peptides to a precise “zip code” in the blood vessels of tumors to deliver a more devastating attack on cancer while sparing normal tissues. The effectiveness of this approach has been demonstrated in the treatment of cancer in mice. Drs. Arap and Pasqualini have designed, built, evaluated and validated a delivery system that relies on a hybrid virus equipped with a targeting peptide to find and genetically mark tumors for imaging. They are advancing this combinatorial screening for use in cancer patients.
Renata Pasqualini is the Helen Buchanan & Stanley Seeger Professor of Medicine and Cancer Biology with appointments in Department of Genitourinary Medical Oncology and the Department of Cancer Biology at The University of Texas M. D. Anderson Cancer Center. She received her doctorate in biochemistry from the Ludwig Institute for Cancer Research at the University of Sao Paulo, Brazil, in 1990. She completed post-doctoral research fellowships at Harvard Medical School, Dana Farber Cancer Institute and The Burnham Institute in La Jolla, Calif.
Wadih Arap is Hubert L. and Olive Stringer Professor for Cancer Treatment and Research and vice chair in the Department of Genitourinary Medical Oncology. He received his medical degree from the University of São Paulo Medical School in Brazil, where he also did a residency in internal medicine. He completed a fellowship in hematology and medical oncology at Memorial Sloan-Kettering Cancer Center in New York and earned his doctorate in cancer biology from Stanford University. Both are on the faculty of The University of Texas Graduate School of Biomedical Sciences at Houston, a joint program of M. D. Anderson and The University of Texas Health Science Center at Houston.
Engineering - Research Team of Douglas Burger, Ph.D. and Stephen Keckler, Ph.D.
Doug Burger is an adjunct professor of computer science at The University of Texas at Austin, and is also a principal researcher at Microsoft Research where he manages a research group in computer architecture. His current research efforts span computer architecture, new computing technologies, power-efficient computing, mobile computing, data center design, cloud computing services and compilers. At Texas, he co-led the TRIPS project, which has developed and prototyped high performance adaptive computer systems. The TRIPS prototype chips are the widest-issue out-of-order processor designs built to date. His research has been recognized with several awards, including over $20 million in extramural funding while at Texas, a National Science Foundation CAREER Award, a Sloan Foundation Fellowship and the 2006 Association for Computing Machinery (ACM) Maurice Wilkes Award. He received his B.S. in computer science from Yale University and his M.S. and Ph.D. in computer science from the University of Wisconsin-Madison. He joined The University of Texas at Austin in 1999. He is a senior member of the IEEE, chair of ACM SIGARCH and was named an ACM Distinguished Scientist in 2008.
Stephen W. Keckler is a professor of computer science and electrical and computer engineering at The University of Texas at Austin. His research interests include computer architecture, parallel processors, high-performance computing, VLSI design and the relationship between technology trends and computer architectures. He co-led the UT-Austin TRIPS project, which has developed and prototyped high performance adaptive computer systems. As co-director of the Computer Architecture and Technology (CART) Laboratory, Keckler's research has been supported by more than $20 million in extramural funding from DARPA, the National Science Foundation, IBM, and Intel. He is an Alfred P. Sloan Research Fellow, the 2003 winner of the Association of Computing Machinery (ACM) Grace Murray Hopper award, a recipient of a National Science Foundation CAREER award, and a winner of the 2007 President's Associates Teaching Excellence Award at The University of Texas at Austin. He earned a B.S. in electrical engineering from Stanford University and an M.S. and Ph.D. in computer science from the Massachusetts Institute of Technology. Keckler is a senior member of both the IEEE and the ACM, and a member of Sigma Xi and Phi Beta Kappa.
Science - Paul S. Cremer, Ph.D.
Paul S. Cremer, a pioneer in the field of biological interfaces, is a professor of chemistry and holder of the Arthur E. Martell Endowed Chair of Chemistry at Texas A&M University. Cremer received his doctorate in chemistry from the University of California-Berkeley in 1996 and spent two years as the ACS-Irving S. Sigal Postdoctoral Fellow at Stanford University prior to coming to Texas A&M in 1998.
His research group works at the interface of physical chemistry, biochemistry, sensor design, and nanomaterial science. A central focus of the Cremer group has been studies on interfacial water structure and ion-macromolecule interactions (the Hofmeister Effect). In related work, the Cremer laboratory has made major progress toward understanding the mechanism by which urea denatures proteins as well as elucidating the mechanisms involved in ligand-receptor binding at fluid biomembrane interfaces. Many analytical techniques, such as temperature gradient microfluidics, local pH modulation for label-free biosensing, and on-chip binding constant measurements, were invented or developed in the Cremer laboratory.
Cremer’s research excellence has been recognized with a plethora of prestigious awards, including the Pittsburgh Conference Achievement Award (2006), the Sigma Xi Southwest Regional Young Investigator Award (2006), the Robert A. Welch Foundation Norman Hackerman Award in Chemical Research (2006), a Camille Dreyfus Teacher-Scholar Award (2003), an Alfred P. Sloan Research Fellowship (2002), the Beckman Young Investigator Award (2001), a National Science Foundation CAREER Award (2001), the Office of Naval Research Young Investigator Award (2000), the 3M Non-Tenured Faculty Award (2000), and the Research Corporation’s Research Innovation Award (1999). In 2009 he was named a Fellow of the American Chemical Society (ACS). He currently serves as an associate editor for the Journal of the American Chemical Society, the flagship journal of the ACS, as well as on the editorial boards of Chemical Reviews, Langmuir, Surface Science, and Biointerphases.
Technology Innovation - S.V. Sreenivasan, Ph.D.
S.V. Sreenivasan is a Professor of Mechanical Engineering and the Thornton Centennial Fellow in Engineering at the University of Texas – Austin. He also holds a Ph.D. in mechanical engineering from The Ohio State University. His collaborative research at UT with Grant Willson and fellow students has focused on high throughput imprint lithography as applied to high density memory, nano-electronics and photonic devices. Realizing the commercial potential of this research led to his founding of Molecular Imprints, Inc. (MII) in 2001. MII is an Austin-based nanotechnology company that now employs over 145 people and boasts a diverse and highly educated demographic with over 18% of employees having Ph.D.’s, 42% having Master’s degrees and 75% having college degrees. Over the last eight years, S.V. has mentored at least ten students in their academic research who have gone on to become employees of MII. The company’s long-standing relationship with UT is now widely recognized as a model of how top research institutions can partner with business to facilitate bringing new technologies to market. As a successful entrepreneur, Chief Technical Officer and member of the Board of Directors, S.V. continues to provide strategic technical and business leadership for MII. He is now leading interdisciplinary projects to develop tools, masks, materials and processes to deploy Jet and Flash™ Imprint Lithography (J-FIL™), MII’s core technology, as a complete solution for high-volume CMOS and hard disk drive manufacturing. He also is working to develop future market opportunities for J-FIL technology in emerging biomedical and solar energy applications.
S.V. has published over 100 technical articles and holds over 60 U.S. nonmanufacturing patents. He has received several awards for his work including Technology Pioneer Award by the World Economic Forum in 2005, University of Texas Chancellors’ Award for Entrepreneurship in 2007, and The American Society of Mechanical Engineers Leonardo da Vinci Award in 2009. Receipt of the 2009 O’Donnell Award in Technology Innovation is further acknowledgement of his career accomplishments as a scientist and business leader.
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